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DeCS
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Descriptor English:
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Anaplastic Lymphoma Kinase
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Descriptor Spanish:
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Quinasa de Linfoma Anaplásico
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Descriptor Portuguese:
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Quinase do Linfoma Anaplásico
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Synonyms English:
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ALK Kinase
ALK Tyrosine Kinase Receptor
Anaplastic Lymphoma Receptor Tyrosine Kinase
CD246 Antigen
NPM-ALK
Nucleophosmin Anaplastic Lymphoma Kinase
Nucleophosmin-Anaplastic Lymphoma Kinase
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Tree Number:
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D08.811.913.696.620.682.725.400.002
D12.776.543.750.630.002
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Definition English:
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A receptor tyrosine kinase that is essential for development and differentiation of the nervous system in response to secreted growth factors. It phosphorylates the first tyrosine of the Y-x-x-x-Y-Y motif of targets that include PROTO-ONCOGENE PROTEINS C-CBL; INSULIN RECEPTOR SUBSTRATE-1; and MITOGEN-ACTIVATED PROTEIN KINASES, leading to activation of the MAPK signaling pathway and cell proliferation. A chromosomal aberration involving the ALK gene results in its constitutive expression in some cases of NON-HODGKIN LYMPHOMA. |
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History Note English:
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2019 (1994)
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Allowable Qualifiers English:
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Record Number:
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57673
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Unique Identifier:
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D000077548
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Occurrence in VHL:
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Similar:
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DeCS
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